Well I hope your not stuck on the "other" side of a glass wall or ceiling. Life's just to short for that shit. Peace-n-Love
Saturday, December 29, 2007
Friday, December 28, 2007
As we have learned genetic abnormalities in combination with any number of other stresses is the most likely path to cancer. The plethora of known and yet undiscovered genetic abnormalities which predispose one to a problem is daunting. Most MMers have a genetic abnormality impairing out ability to metabolize toxins. Add to that any number of other factors like a TRIAL-R deficiency and you have yet another of the countless ways to aid you in the manifestation of a disease.
So if you won the genetic lottery and happen to have no potential health related genetic abnormalities, are stunningly beautiful, amazingly intelligent, and have miraculously avoided environmental toxins, then I'm jealous. What can I say. You won the lottery and I didn't.
Happy New Year.
Sunday, December 23, 2007
It is the Season when I more often recall and reflect on just how thankful I am to have a world of friends, many I may never meet, who have touched me with their thoughts, prayers, wisdom and experiences. The countless thousands effecting a cure for what ails me. All those brave souls who went on clinical trials. My steadfast caregivers (Lu that's mainly you!) filling my life with joy, touching me with compassion and just being there by my side rain or shine.
May all your lives be blessed. Merry Christmas.
Wednesday, December 19, 2007
Tuesday, December 18, 2007
Ah the beauty of opulent over expression, OCD, and a love of electricity.
Instead I have a tiny 3 foot tree top (what I left behind will live...) from the back 40 decorated with colored rice lights. I find sanctuary in the simplicity. Then again there won't be any kids (or grandchildren) that need spoiling this year. :-)
Sunday, December 16, 2007
But the fire is so delightful,
And since we've no place to go,
Let It Snow! Let It Snow! Let It Snow!
I just love the view out my bedroom window, especially on days like this. The old treadle sewing machine is slowing being buried in fluffy white stuff.
Saturday, December 15, 2007
I definitely had enough sugar today to blow away any anemia issues. You can't help licking your fingers, popping a M & M, and at least trying the egg nog. A bit of sing-along Christmas music, the children and their friends all came together leaving me with a big smile here at the end of the day. Lu gathered up the coolest construction candy ever this year. Most of it is totally disgusting, but it is awesome construction material. Tony mastered the frosting and brought the most wonderful coloring. We even had black frosting for the snowman's buttons. There is something that warms the soul when you spend a day laughing and being creative with people you love. It's got to be good for whatever ails me. :-)
Thursday, December 13, 2007
It is the fresh clean look that got me thinking about where or when I might have strayed into some ugly environmental toxin. Dr. Durie, chairman of the IMF, gave a presentation on the genetic finding from the myeloma DNA Bank on a Cure.
The study found that genetic pathways associated with the ability to neutralize environmental toxins are defective in patients with classic myeloma. "Identifying these genetic pathways was unexpected," said Brian G.M. Durie, M.D. "We were looking at bone biology and the SNPs associated with toxin metabolism fell into place. Now, working back through the gene pathways, we have a robust model of myeloma bone disease that may explain the epidemiological observations." [ref]
This is exciting news for my grand children. We may be able to identify those individuals most susceptible to environmental toxins and advise them of appropriate precautionary measures. Linking these finding to clinical therapies effecting a cure would really brighten my day.
Wednesday, December 12, 2007
Tuesday, December 11, 2007
In short, recent RBS (restless body syndrome) is not because of sugar control issues and probably not because of drugs. How about spending too much time in a lousy bed because I'm fatigued with too much stress because I don't like having myeloma any more. Hmmm Well I'm sure you'll find out if the myriad of orders I got has any effect. A few hours after leaving the clinic I spent an hour with my therapist. I'm fixed now. All better. I wonder what shape I'll be in by this time tomorrow...
Monday, December 10, 2007
Sunday, December 09, 2007
In addition to BiP and Herp, three other members of the menagerie, Derlin-1, p97 and Hrd 1 collaborate with Herp to extract defective proteins from the retrotranslocon so Herp can hand it over to the proteasome.
Need I say more! The sad part is if I didn't know the terms or names I looked them up and actually liked the article in Molecular Cell. I think I should go read a romance novel now.
Saturday, December 08, 2007
Thursday, December 06, 2007
I have been playing that tune all day. I am so psyched to not have to deal with all the headaches of treatment and feeling like shit afterwards. Merry Christmas to me. Ya God. Thank you thank you thank you.
Tuesday, December 04, 2007
Guess what I got to bring home with me today... the GRN163L clinical trial protocol. This is a single agent Phase I does escolation study with a weekly 2 hour infusion (and clinical trial related blood work, etc. etc. etc.) Although there is a relatively short history with GRN163L my impression after spending a considerable amount of time with the research nurse and oncologist was the side effects appear pretty tame and the potential efficacy being significant (at least for the CLL Trial). A single patient (out of about a dozen) experienced poor blood clotting ability (PT/INR).
There is no clinical MM efficacy to relay as the study has not yet recruited a single patient.
Monday, December 03, 2007
I happen to be getting the standard skeletal surveys which are a poor indicator of disease response. For starters bone lesions don't get smaller if you have a great response. There is some evidence that bone regrowth will occur, but it is a very slow process if it does. I have had a couple bone marrow MRI's done over the course of the past 2 years. They have the added benefit of no ionizing radiation and the potential for accessing bone marrow involvement albeit with low precision. So were do I end up... looking for cutting edge myeloma imaging techniques. There is a group of researchers in Germany working on PET markers for MM. The standard PET marker basically measures glucose uptake which is supposed to be higher in tumors than healthy tissue. The trick with PET markers is to find one that is specific to what you want to image and has sufficient uptake that the scanner can actually see it. I think there is an imaging question for a bunch of mechanical engineers to be had here. Hee hee hee. If you cut through the big words it boils down to is there enough "light" and is everything else dark. Another group from Cambridge, UK, has developed an exciting imaging technique called magnetic resonance spectroscopy (MRS) which is specific to changes in lactate dehydrogenase (LDH). MMer's know all about LDH. I get mine tested twice a week during this clinical trial. A change in LDH level in myeloma cells can be correlated with the amount of cell death and can therefore provide very early feedback of the efficacy of a particular therapy.
Nobody wants to keep taking a drug that isn't working. I sure would like to know if what I am taking is working! I'll let you know tomorrow. :-)
Sunday, December 02, 2007
Many of the myeloma therapies (and other cancer therapies as well) have peripheral nerve issues ranging from permanent debilitating damage to annoying sensory disruptions. The possibility that myelin sheath integrity could be enhanced by a JAM-C therapy thereby alleviating a nasty side effect is exciting news.
Embryonic stem cells derived from skin made the news this week also. [Cell, Science] The lead investigator gave as an example of potential therapy, nerve regeneration. Again stressing years (not decades) before any therapeutic use would be realized. My lingering question was if you can derive embryonic stem cells from skin cells how about hematopoietic stem cells (that don't produce dysfunctional B-cells)?
Saturday, December 01, 2007
"This process changes the way we look at blood stem cells," says von Andrian. [ref]
As an example of how you can start from a simple press release for a local clinical trial targeting myeloma stem cells (using GRN163L) through the beating-myeloma.org Cancer-Stem-Cells post to this little rant. :-) I just love learning more only to be humbled by more questions.
Thursday, November 29, 2007
Some food for thought before meditating...
Wednesday, November 28, 2007
Now for some mindfulness-based stress reduction!
Tuesday, November 27, 2007
I bet I wasn't in my seat a minute before being summoned to have my skeleton surveyed. How cool is that. Twenty five x-rays all in slightly awkward poses. Deep breath, hold. Exhale, hold. Pray. Toes in. Palms up. yada yada yada. I promptly went to work and simply glowed for the rest of the day. That "Oh gee, you look sort of fluorescent. What's up with that." "I'm fine just don't hang out in my office very long."
Oh yea and there is a hole in my head.
Monday, November 26, 2007
Sunday, November 25, 2007
I try to keep this blog lite and humerus. It certainly helps my level of stress. Here is a rant that is lite on the humor...
There is a ton of scientific data demonstrating that the chemical messengers coming from our brain cells carry messages to the immune cells. The reverse is also true. Our immune cells release messenger molecules which the nervous system uses to provide feedback information to the brain or other organ systems. Dr. David Simon likes to use the phrase, "Our immune cells are eavesdropping on our internal conversation." If this is indeed the case what can one do to enhance this internal dialog to strengthen our immune system.
Diet: Remember the phrase "You are what you eat." I believe there are many more levels to that than nutritional. How was what you are eating created? Was it mass produced and then slaughtered ruthlessly or grown by a local farmer who shares your values? What you consume effects the whole planet as well as your body. I call it mindful munching. There are several MM bloggers seriously minding their munching. I just read a pretty convincing article "Surviving Against All Odds: Analysis of 6 Case Studies of Patients With Cancer Who Followed the Gerson Therapy" Gerson therapy is an example of extremely mindful munching. This review clearly implicates a connection between what we eat and tumor progression. Case 4 was a remotely related malignancy, non-Hodgkin lymphoma, which was graded at stage IIIa in 1999 and as of August 2001 has been judged free of disease.
Meditation: Mindfulness-based stress reduction (MBSR) is the most frequently found term in the medical literature relating to "meditation" and cancer. I could find no articles in which negative efficacy was attributed to cancer patients enrolled in a MBSR. Although very few well controlled studies have been done the literature reviews [1, 2] place the techniques in a favorable light suggesting potential benefit in the oncology setting. It is my belief that quieting the mind on a regular basis will send calming signals to the immune system. On that note I guess emotional toxins probably lead to physical toxicity as well.
Thats enough for one day don't you think?
Saturday, November 24, 2007
Friday, November 23, 2007
Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress,
Thomas H. Huxley
"The great tragedy of Science - the slaying of a beautiful hypothesis by an ugly fact."
Thursday, November 22, 2007
Wednesday, November 21, 2007
"Now we can rationally design drugs that enhance bortezomib's action and favor NOXA production," she says. "Improvements might make it possible to give lower doses of the drug for a shorter time." [Medical News Today]
I for one would like to take significantly less bortezomib. It feels like there is a bit too much programed cell death going on in my muscles (and head.) The UM study focused on melanoma which I should now have a much lower chance of ever developing. Ye ha.
If the folks at MIT could just Remote-Control a few billion Nanoparticles to Deliver Drugs Directly Into my laughing plasma cells I'd be all set.
Tuesday, November 20, 2007
I will spare you any conjecture from these finding. If you didn't agree with me it might be stressful. :-)
-- source --
Stress Hormone can Speed Cancer, By: Rick Nauert, Ph.D. Senior News Editor, Reviewed by: John M. Grohol, Psy.D. on November 20, 2007, http://psychcentral.com
Monday, November 19, 2007
If after the battle is won those discharged plasma cells don't bugger off and die you have some form of myeloma. Lets hope it is a benign manifestation of no significance (like MGUS). If you have a bunch of confused disorientated and delusional top brass (like the Bush administration) they may be activating plasma cells without an enemy. The plasma cells keep fighting, shooting blanks (antibodies specific to an invader that doesn't exist). Things can get really out of control. The army can get so bloated and out of control that they start crowding out everything else in the environment (the bone marrow), send erroneous signals to the rest of immune system and plug up other systems (like the kidneys) with useless antibodies.
In my case one of the things my intoxicated laughing plasma cells are doing is signally the rest of my immunity system to shut down. "Don't bother waking up, sleep in, everything is taken care of." All my useful fighters (immunoglobulins) are slowly being lulled into submission. Here is a graph of my immunoglobulin expression since this out of control army was found back at the end of 2005. There are now about 10 times fewer immunoglobulins than there should be. That is a good incentive to be neurotic about what I expose my self to.
Sunday, November 18, 2007
My laughing plasma cells partied to much and no longer know how to make the heavy part. They spew nothing but unbound free light chains. To add insult to injury the little bastards are very aggressive. Frits van Rhee et al published a paper a few months back in the journal Blood titled "High Serum Free-Light Chain Levels and Their Rapid Reduction in Response to Therapy Define an Aggressive Multiple Myeloma Subtype with Poor Prognosis". To the careful eye you will see in the graph below that my lambda light chain level responded in the first cycle of Thal/Dex and then promptly started ignoring the drugs. I wish Frits had published his paper back in February of 2006. I would have stopped taking Thal/dex after a couple months. I am anxiously awaiting the next free light chain (FLC) results to see if Velcade and the TRM-1 antibody turns the lights out on my plasma cell party.
Friday, November 16, 2007
To average all things out we went to Chesters (Cajun) for dinner and waited forever for a table. We decided to not go there on Fridays last week. Brain Fart. Great food and friends are the ultimate anesthetic. I probably won't remember how long the wait was the next time they call either.
Velcade does a nice job of screwing with platelet counts. During treatment they drop precipitously and then pop back up during the week off. My RBC (red blood cell count) is unfortunately steadily dropping. I have to wait a couple more weeks to see the important markers.
Thursday, November 15, 2007
I am most thankful for 10 weeks of bliss. A few short walks around the infusion clinic and I feel like a million bucks. Boy do I have a great life. In fact I'll kick some ass on the tennis court in the morning. Teach that little yellow ball a lesson or two.
Tuesday, November 13, 2007
I am working on reducing this whole ordeal to the level of a bowel movement. Something I just do. I never remember the last one or wake up at night worrying about the next one. On rare occasion they are a pain in the ass. More often than not they just happen without a conscious thought.
Monday, November 12, 2007
Combine SAD with hot flashes and you get the 5 dwarfs: Weepy, Piggy, Bloaty, Bitchy and Crampy. Two of the dwarfs, Horny and Red-Tide are in the Caribbean.
Sunday, November 04, 2007
My baby boy turned 26 yesterday. Yup I'm a proud Dad. I'm still reminiscing of the pure ecstasy brought on by a gluten free chocolate cupcake.
Wednesday, October 31, 2007
So it took an extra week for the lab techs to determine they were "Unable to Quantitate" my M-spike. Seeings how I started with "None" I should not try to quantify "Unable to Quantitate". My official clinical trial "Response Report" summarizes the findings as "Stable Disease".
Now to add a nice twist (or rant) to all this. My lovely mutation does not express an M-spike and therefore watching it is a stupid idea. Name calling is inappropriate though. So I watch the levels of a particular light chain protein which is monitored with a serum free light chain assay or a similar urine electrophoresis free light chain test. Over the last 2+ months my expression of lambda free light chains has dropped from about 1500 to 1000 (mg/dL) after a trend of doubling every 2 months previously.
I'm going with the optimistic perspective on the "Stable" interpretation.
Tuesday, October 16, 2007
As for the boring details: Two courses down with nothing exciting to report other than reporting nothing exciting is exciting to me. Funny how the mundane becomes significant when threatened. My blood counts trend down for 2 weeks and then bounce back during my week off. On Friday every line in my CBC and CMP was within normal ranges. I'll learn next week if any myeloma significant markers have changed.
So, I'm off to see the wizard... with my orange buckets and plump veins.
Wednesday, September 26, 2007
Velcade often causes gas (and worse blowouts). It is a potent chemical weapon causing facial contortions. So I have the week off. (from Roswell at least!) We celebrated with a quick trip to the Adirondack balloon festival this past weekend.
There is nothing more wonderful than being surrounded by love and laughter. Friends and family from all over the country made for a weekend I'll always remember.
My nephews specialize in anarchy. So I got the younger one a CB radio for his birthday. We built a fire to destroy things in. I think explosives are needed. Ma and Dad 'll appreciate that I'm sure. They live 3000 miles away so we should be safe on the east coast.
Wednesday, September 19, 2007
Saturday, September 15, 2007
My dear friend Joanie won her battle with breast cancer this week. Great news in a difficult to articulate, tough to deal with sort of way. It is wonderful having friends you can count on for a laugh and a smile. Those special few who somehow just shine despite the weather. I am blessed with memories of Joanie shining brighter than ever, burning off some of that fog that settled in like pea soup, stranding me panicked scared and lost while out cruising on the Cancer Parkway. I am honored to have such a beacon shining in the here-after. Shine on girl friend.
Oh yea and that Friday evening trip down the Parkway to Velcade has left me feeling just fine. Nice place, no fog!
Thursday, September 13, 2007
I am happy to report that no unusual regurgitations have occurred. Just the normal verbal drool. I can see just fine. Of course the weird headache and runny nose must fall under one of the 3 pages of potential side effects somewhere. I couldn't just have the sniffles. No hysteria in that! When I stop laughing about this crazy journey of mine you'll know they finally gave me some nasty shit to shut me up.
Wednesday, September 12, 2007
In short I was randomized in the clinical trial to receive the high dose of TRM-1 (a Fully Human Monoclonal Antibody to TRAIL-R1 which appears to have some anti-myeloma efficacy). So after I received the Velcade and a 1 hour infusion of TRM-1 I sat around for 4 hours to make sure I didn't have an allergic reaction. Hence all the measure and wait crap.
The Benadryl they gave me knocked me out by 8. Now I just feel like I had a lousy breakfast. I'll be watching for these especially exciting Velcade side effects:
- vomiting material that looks like coffee grounds (I filter my coffee)
- inability to speak or understand speech (normal interaction with colleagues)
- loss of memory (normal, besides how would I know?)
- loss of vision (after the memory loss would be preferred)
- difficulty thinking clearly (maybe Lu could comment on these?)
- difficulty using good judgment (normal)
- difficulty understanding reality (normal)
Provided I can see if I hurl coffee grounds you all will have to let me know if I seem to be especially "normal" in some unique way.
Wednesday, August 29, 2007
We switched to a Tuesday morning & Friday after class schedule (so I can continue to escape on the weekends).
This past weekend my soul was touched by many dear old friends. It is absolutely wonderful to be graced with life long friends.
Tuesday, July 24, 2007
I'll bolster my defense team for that anti TRAIL-R1 docket NCT00315757 I mentioned a while back over the next month. The bolstering will come in the form of heightened creativity leading to effortless productivity while enduring lots of lakeside captivity.
Tuesday, July 17, 2007
In the mean time I will continue to jump away on the water trampoline and try not to get sun burned.
Wednesday, June 13, 2007
Lu's stroke of brilliance this month was purchasing a time share in Lincoln City on the Oregon coast (for the same price as renting the place.) Here we are in awe of the amazing view from the front deck. My therapy this week was to raise my cellular vibration by communing with nature. Walks on the beach, hikes in the woods, birding, wonderful drives along the coast and a temporary bit of sand art to gaze at out the front door.
Tuesday, May 29, 2007
So in another week and a half I'll let you know what they found. A vacation in the meanwhile sounds good to me.
Thursday, May 17, 2007
Skipping and paraphrasing her message: Have you ever been driving along on a rather normal morning and suddenly wham your in a bank of fog so thick you can't see out of the car. Your panicked... should I stop, no I'll get rearended... should I pull over, where is the road? am I on the road? am I going to crash into something. freaked... panicked... scared... Well on December 27, 2005 when the doctor said to Scott you have multiple myeloma, I drove into the thickest bank of fog I have ever known. Stranded, alone and scared in a fog so thick I couldn't even think.
Then there are tail lights, faintly glowing red in the fog. Some sense of relief, I'm not alone. Those red tail lights are like the Red Door at Gilda's Club. A light in the fog. A place where I am not alone in this fog.
Well as she walked off stage I stood tears streaming and reached out for a hug. What I next saw was 700 hundred people all standing, many crying, all clapping.
It was a moving way to say thank you to all those benefactors who help make Gilda's Club a sanctuary of hope and companionship for those of us touched by cancer.
Wednesday, May 09, 2007
Then we left for Hot Springs Arkansas to boil my blood. Oh golly what a grand opulent pampered luxurious adventure. Thermal waters pumped right into our hotel room. Three baths a day, in addition to the pool, hot tub, and of course quartz crystal mining. Being the rock hounds that we are there was plenty of barking at the moon.
Drove right by and waved at the Little Rock medical center and Mr. Myeloma and his Total Therapy III. I'm not up for total therapy. In fact I want as little therapy as possible.
Thursday, April 19, 2007
Wednesday, April 18, 2007
So I'm asked to be on a "panel" at the Worldwide Gilda's Club annual meeting today. I'm a reasonably articulate engineer type. I make a living teaching... "Sure, I'd be glad to."
So there I am on stage in a comfy chair with my wife, Lu, to my the right and a few friends. Talk show, aka David Letterman, style. A small studio audience of about a hundred. Half the size of my fall "Intro to Computers and Instrumentation" class.
Start of the show, Letterman lobs the softball, "What does Gilda's mean to you." I start with "I'm an engineer. A pretty accomplished control freak. Behind that Red Door"... long pause, composure crumbling.......... tears streaming down my face, all choked up, I look up and see everyone else has joined in the fun. As Rosana Rosanadana would put it, "I thought I was gonna die!" I just hand the mic to Lu who gives me that "Thanks a lot, how am I supposed to follow that!" look. Needless to say I guess my message got across without actually having to say anything.
So after a standing ovation and a real talk show offer I'm not totally ashamed.
You want an idea of what Gilda's has to offer? Put yourself in the car, nice summer day, cruising along and all the sudden there's a squirrel right in front of you. Frozen, no darting, frozen, darting, back in your lane, gone -- your nails are dug into the wheel, the FREAKED ADRENALINE RUSH is passing.
Well I'm the squirrel. I look up, there is this enormous thundering beast with Myeloma scrolled across the grill barreling down on me at 60 MPH. I can't run, I'm paralyzed, spassed out, out of control, can't fix it, what to do - oh shit. Gone. Unfortunately I gotta cross that road every day, about 50 times. It's not an expressway thank God. Most of the time there aren't even any cars. I might even go a day without a bit of traffic.
I go to Gilda's to hang with the squirrels. To laugh a lot as you can imagine us squirrel like to do. The traffic takes its toll, but us squirrels got a way of pulling together and finding those acorns.
Sunday, April 08, 2007
Just what is it about spontaneous expression of ones soul that livens the spirit? Is it our uniqueness that is the enduring distinct entity, the spiritual part that longs for resurrection not just on Easter, but every day?
Well don't turn to me for answers. It is that very uniqueness that I struggle to uncover, to resurrect from my depths and bring to life. That creative spear chucking native spirit is coming out to play.
Some summer weather would help with the new look, but I'll go with the Eskimo genre on this snowy Easter.
Thursday, April 05, 2007
I just wanted to laugh a bit after all the hysteria surrounding my court case. Any suggestions? I like a dry merlot humor with a hint of sex.
I gave my final exam today. A cross registered grad/undergrad class, Cardiovascular Biomechanics. How come all the undergrads felt compelled to ignore questions and finish the exam before any of the grads? Something about the math questions seemed to scramble their brains. Couldn't have been the instructor could it?
Wednesday, April 04, 2007
Click here to sing along...
Mr. Sandman, bring me a dream
Make me the happiest that I've ever been
Give me new bones strong as bulldozers
Then tell me that my fearful nights are over.
Sandman, I'm not alone
I have somebody to call my own
Please turn on your magic beam
Mr. Sandman, bring me a dream.
Mr. Sandman, brought me a dream.
Made me the happiest that I've ever been
Gave me the word that my kidneys are safe
Then told me that my labs were just chafe
Mr. Sandman, I'm not alone
I've got someone to call my own
I'm the luckiest you've ever seen
Mr. Sandman, brought me a dream
Mr. Sandman bring me a dream
Tell Lu her pair of eyes have a "come-hither" gleam
I've not a lonely heart like Pagliacci
but a throbbing one like Liberace
Mr. Sandman, someone to hold
Would be so peachy before we're to old
So please turn on your magic beam
Mr. Sandman, bring us, please, please, please
Mr. Sandman, bring us a dream
Monday, April 02, 2007
He sprinkled sand like you wouldn't believe. I went to inspect the new septic system at the camp. We now have a hay covered beach want-a-be right next to the deck. It's hard to get all freaked out over sand, but this is weird. I wasn't expecting the side yard to be 3 feet higher. Truth be told I didn't really think about it. I just figured the lawn would be a mess and we would deal with it.
It needs pink flamingos and a pony to eat the hay.
Sunday, April 01, 2007
We closed on a lake front piece of heaven on earth on Lu's birthday (how fortuitous!) a couple months ago. I've got a serious itch for those idyllic warm low humidity long summer day. I learned there is no recorded temperature above 100 in Buffalo (we have hit 99F) and the lakes (usually) keep the humidity comfortably low.
Come on let me have it.
gimme gimme gimme,
whine whimper stomp and pout
can't you hear me shout!
Saturday, March 31, 2007
I did worse than before on the makeup tests. Trick questions I guess. I didn't study very hard for the urine test.
Saturday, March 24, 2007
I'm on a light chain gang pending arraignment and a preliminary hearing. I guess in this system speedy trials are reserved for the well connected. I get 3 decent meals a day, but have to deal with emotional baggage all day. They want to install a mediport no doubt to make tracking and manipulation of me easier. This is all so ethereal. I just know they got the wrong guy.
Tuesday, March 20, 2007
So not unlike the climate change deniers, my plasma cells have morphed their stance to fit the current climate. They got pissed at the drugs screwing with their climate and developed a new found fetish for light chains. No more classic M-spike, no more mild mannered reporting. The only way to see what's up is to give them a "free light test". My highly technical understanding is: if you give someone something they have a fetish for they get all excited and light up. So when you offer them free lights apparently they turn on all the light chains so you can see them. It's called light chain disease.
I'm not sure what that means in terms of life and death, but I'm pissed off. I wanted a full decade of denial, or at least a year. I didn't even get 3 full months! There are 10 times as many light chains now as there was 3 months ago. So I'm shopping for a clinical trial with my oncologist. I'll let you know in a couple weeks what we decide to buy.
Friday, January 05, 2007
I'll spare you the 2006 monkey minded end of the year recap. We did lots of really intense stuff.