Thursday, November 29, 2007
Some food for thought before meditating...
Wednesday, November 28, 2007
Now for some mindfulness-based stress reduction!
Tuesday, November 27, 2007
I bet I wasn't in my seat a minute before being summoned to have my skeleton surveyed. How cool is that. Twenty five x-rays all in slightly awkward poses. Deep breath, hold. Exhale, hold. Pray. Toes in. Palms up. yada yada yada. I promptly went to work and simply glowed for the rest of the day. That "Oh gee, you look sort of fluorescent. What's up with that." "I'm fine just don't hang out in my office very long."
Oh yea and there is a hole in my head.
Monday, November 26, 2007
Sunday, November 25, 2007
I try to keep this blog lite and humerus. It certainly helps my level of stress. Here is a rant that is lite on the humor...
There is a ton of scientific data demonstrating that the chemical messengers coming from our brain cells carry messages to the immune cells. The reverse is also true. Our immune cells release messenger molecules which the nervous system uses to provide feedback information to the brain or other organ systems. Dr. David Simon likes to use the phrase, "Our immune cells are eavesdropping on our internal conversation." If this is indeed the case what can one do to enhance this internal dialog to strengthen our immune system.
Diet: Remember the phrase "You are what you eat." I believe there are many more levels to that than nutritional. How was what you are eating created? Was it mass produced and then slaughtered ruthlessly or grown by a local farmer who shares your values? What you consume effects the whole planet as well as your body. I call it mindful munching. There are several MM bloggers seriously minding their munching. I just read a pretty convincing article "Surviving Against All Odds: Analysis of 6 Case Studies of Patients With Cancer Who Followed the Gerson Therapy" Gerson therapy is an example of extremely mindful munching. This review clearly implicates a connection between what we eat and tumor progression. Case 4 was a remotely related malignancy, non-Hodgkin lymphoma, which was graded at stage IIIa in 1999 and as of August 2001 has been judged free of disease.
Meditation: Mindfulness-based stress reduction (MBSR) is the most frequently found term in the medical literature relating to "meditation" and cancer. I could find no articles in which negative efficacy was attributed to cancer patients enrolled in a MBSR. Although very few well controlled studies have been done the literature reviews [1, 2] place the techniques in a favorable light suggesting potential benefit in the oncology setting. It is my belief that quieting the mind on a regular basis will send calming signals to the immune system. On that note I guess emotional toxins probably lead to physical toxicity as well.
Thats enough for one day don't you think?
Saturday, November 24, 2007
Friday, November 23, 2007
Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress,
Thomas H. Huxley
"The great tragedy of Science - the slaying of a beautiful hypothesis by an ugly fact."
Thursday, November 22, 2007
Wednesday, November 21, 2007
"Now we can rationally design drugs that enhance bortezomib's action and favor NOXA production," she says. "Improvements might make it possible to give lower doses of the drug for a shorter time." [Medical News Today]
I for one would like to take significantly less bortezomib. It feels like there is a bit too much programed cell death going on in my muscles (and head.) The UM study focused on melanoma which I should now have a much lower chance of ever developing. Ye ha.
If the folks at MIT could just Remote-Control a few billion Nanoparticles to Deliver Drugs Directly Into my laughing plasma cells I'd be all set.
Tuesday, November 20, 2007
I will spare you any conjecture from these finding. If you didn't agree with me it might be stressful. :-)
-- source --
Stress Hormone can Speed Cancer, By: Rick Nauert, Ph.D. Senior News Editor, Reviewed by: John M. Grohol, Psy.D. on November 20, 2007, http://psychcentral.com
Monday, November 19, 2007
If after the battle is won those discharged plasma cells don't bugger off and die you have some form of myeloma. Lets hope it is a benign manifestation of no significance (like MGUS). If you have a bunch of confused disorientated and delusional top brass (like the Bush administration) they may be activating plasma cells without an enemy. The plasma cells keep fighting, shooting blanks (antibodies specific to an invader that doesn't exist). Things can get really out of control. The army can get so bloated and out of control that they start crowding out everything else in the environment (the bone marrow), send erroneous signals to the rest of immune system and plug up other systems (like the kidneys) with useless antibodies.
In my case one of the things my intoxicated laughing plasma cells are doing is signally the rest of my immunity system to shut down. "Don't bother waking up, sleep in, everything is taken care of." All my useful fighters (immunoglobulins) are slowly being lulled into submission. Here is a graph of my immunoglobulin expression since this out of control army was found back at the end of 2005. There are now about 10 times fewer immunoglobulins than there should be. That is a good incentive to be neurotic about what I expose my self to.
Sunday, November 18, 2007
My laughing plasma cells partied to much and no longer know how to make the heavy part. They spew nothing but unbound free light chains. To add insult to injury the little bastards are very aggressive. Frits van Rhee et al published a paper a few months back in the journal Blood titled "High Serum Free-Light Chain Levels and Their Rapid Reduction in Response to Therapy Define an Aggressive Multiple Myeloma Subtype with Poor Prognosis". To the careful eye you will see in the graph below that my lambda light chain level responded in the first cycle of Thal/Dex and then promptly started ignoring the drugs. I wish Frits had published his paper back in February of 2006. I would have stopped taking Thal/dex after a couple months. I am anxiously awaiting the next free light chain (FLC) results to see if Velcade and the TRM-1 antibody turns the lights out on my plasma cell party.
Friday, November 16, 2007
To average all things out we went to Chesters (Cajun) for dinner and waited forever for a table. We decided to not go there on Fridays last week. Brain Fart. Great food and friends are the ultimate anesthetic. I probably won't remember how long the wait was the next time they call either.
Velcade does a nice job of screwing with platelet counts. During treatment they drop precipitously and then pop back up during the week off. My RBC (red blood cell count) is unfortunately steadily dropping. I have to wait a couple more weeks to see the important markers.
Thursday, November 15, 2007
I am most thankful for 10 weeks of bliss. A few short walks around the infusion clinic and I feel like a million bucks. Boy do I have a great life. In fact I'll kick some ass on the tennis court in the morning. Teach that little yellow ball a lesson or two.
Tuesday, November 13, 2007
I am working on reducing this whole ordeal to the level of a bowel movement. Something I just do. I never remember the last one or wake up at night worrying about the next one. On rare occasion they are a pain in the ass. More often than not they just happen without a conscious thought.
Monday, November 12, 2007
Combine SAD with hot flashes and you get the 5 dwarfs: Weepy, Piggy, Bloaty, Bitchy and Crampy. Two of the dwarfs, Horny and Red-Tide are in the Caribbean.
Sunday, November 04, 2007
My baby boy turned 26 yesterday. Yup I'm a proud Dad. I'm still reminiscing of the pure ecstasy brought on by a gluten free chocolate cupcake.