Tuesday, November 20, 2007

Stress Hormone

It certainly isn't a surprise that stress might have an impact on ones health. It is interesting that someone looked at the effect of a stress hormone, norepinephrine, on myeloma cell lines. The early disease stage cell line responded strongly to the hormone. The implication proposed was that the hormone stimulated the production of new blood vessel growth (up regulation of VEGF) which is needed for the proliferation of the malignancy.

The researchers believe that blocking these receptors would slow the process of the growth of more blood vessel to the tumor, delaying disease progression and perhaps allowing treatments to be more effective. Widely used “beta-blocker” drugs now prescribed for high blood pressure work by blocking these same particular cell surface receptors, Yang said.

I will spare you any conjecture from these finding. If you didn't agree with me it might be stressful. :-)

-- source --
Stress Hormone can Speed Cancer, By: Rick Nauert, Ph.D. Senior News Editor, Reviewed by: John M. Grohol, Psy.D. on November 20, 2007, http://psychcentral.com


Margaret said...

Interesting post, L.C. One of many, I would add. This one in particular caught my attention, because I have been intending for some time to write a post on the connection between stress and increased IL-6 levels. I will get around to doing that...someday. There is an interesting study on the effects that chronic stress and age-related have on IL-6: http://medicine.osu.edu/mindbody/pdf/chronic_stress_and_age.pdf Depression also is an IL-6 increase factor. So, in sum, we have lots of reasons to remain happy and upbeat, even when we aren't having sunny days! :-) Margaret

Beth said...

IL-6 is also a known growth factor for MM. I was in an anti-IL-6 study a few years ago for a MAB called CNTO 328. It didn't help my MM, but they're still conducting trials, so it may be helping others.